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KMID : 0363819910250020286
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Korean Journal of Nuclear Medicine
1991 Volume.25 No. 2 p.286 ~ p.293
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The Development of Iodine-123 with MC-50 Cyclotron
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서용섭/Suh, Yong Sup
양승대/전권수/이종두/한현수/Yang, Seung Tae/Chun, Kwon Soo/Lee, Jong Doo/Han, Hyon Soo
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Abstract
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1231, which is applied for the thyroid and other in vivo kinetic study, has a special role in life sciences. The 159 KeV 7-ray from 1231 is almost ideally appropriate for the current imaging instrumentation. Its decay mode (electron capture) and short half-life (13.3 hr) reduced the burden of radiation dose to the patients, and its chemical property makes it easy to synthesize the labelling compounds.
In this experiment, the production of 123I via the nuclear reaction 324Te(p,2n)1231 with 28 MeV protons was sutdied. Te02 is used as a target material, because it has good physical properties. The target was prepared with Te02 powder and was molten into a ellipsoidal cavity (a = 14 mm, b = 10 mm, 270.8 mg/cm´ thick) of pure platinum. The irradiation was carried out in the external proton beam with incident energies range from 28 MeV to 22 MeV, and current was 30pA. The loss of Te02 target was significantly reduced by using 4r-cooling system in irradiation.
The dry distillation method was adopted for the separation of 1231 from irradiated target, and when it was kept 5 minutes at 780°C, its result was quantitative. The loss of the target material (Te02) was below 0.2% for each production run and 1231 from the dry distillation apparatus was captured with 0. 01 N NaOH in Na1231 form, then the pH of the solution was adjusted to 7.5-9.0 with HC1/NaOH.
The Na123I solution was passed through 0.2pm membrane filter, and sterilized under high pressure and temperature for 30 minutes.
The production of 1231 is acceptable for clinical application based on the quality of USP XXI.
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